A flexible motif search technique based on generalized profiles

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Julie Thompson, Desmond G. Higgins, Toby J. Gibson · Nucleic Acids Research · 1994 · 64.9K citations · Full text

Life Sciences, Bioinformatics, Sequence Analysis +14

A tutorial on hidden Markov models and selected applications in speech recognition

L. R. Rabiner · Proceedings of the IEEE · 1989 · 22.8K citations

Computing, Computer Science, Machine Learning +11

A general method applicable to the search for similarities in the amino acid sequence of two proteins

Saul B. Needleman, Christian D. Wunsch · Journal of Molecular Biology · 1970 · 11.5K citations

Life Sciences, Biochemistry, Bioinformatics +13

Amino acid substitution matrices from protein blocks.

Steven Henikoff, Jorja G. Henikoff · Proceedings of the National Academy of Sciences · 1992 · 6.4K citations

Life Sciences, Bioinformatics, Evolutionary Biology +16

A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure

James U. Bowie, Roland Lüthy, David Eisenberg · Science · 1991 · 2.9K citations

Life Sciences, Biochemistry, Bioinformatics +14