Co-occurrence of anxiety and depressive-like behaviors following adolescent social isolation in male mice; possible role of nitrergic system

Depression: a new animal model sensitive to antidepressant treatments

Roger D. Porsolt, Manuel Pichon, M Jalfre · Nature · 1977 · 4.4K citations

Medicine, Neuroscience, Psychiatry +12

Loneliness and Health: Potential Mechanisms

John T. Cacioppo, Louise C. Hawkley, Lori Crawford et al. · Psychosomatic Medicine · 2002 · 1.2K citations

Nursing, Physiology, Psychology +17

Comorbidity of DSM–III–R Major Depressive Disorder in the General Population: Results from the US National Comorbidity Survey

Ronald C. Kessler, Christopher B. Nelson, Katherine McGonagle et al. · The British Journal of Psychiatry · 1996 · 1.1K citations

Social Sciences, Behavioral Sciences, Psychiatry +17

Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat

Isabelle Weiss, Christopher R. Pryce, Ana L. Jongen‐Rêlo et al. · Behavioural Brain Research · 2003 · 518 citations

Life Sciences, Neurobiology, Neuroscience +14

Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice

Hiroshi Takeda, Minoru Tsuji, Teruhiko Matsumiya · European Journal of Pharmacology · 1998 · 457 citations

Medicine, Neurobiology, Neuroscience +6