Concepedia

Control of Homeostasis of CD8 <sup>+</sup> Memory T Cells by Opposing Cytokines

Chia‐Chi Ku, Masaaki Murakami, Akemi Sakamoto, John W. Kappler, Philippa Marrack

Science · 2000 · 817 citations · 40 references

Abstract

Memory T cells maintain their numbers for long periods after antigen exposure. Here we show that CD8+ T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2). Therefore, the numbers of CD8+ memory T cells in animals are controlled by a balance between IL-15 and IL-2.

References

40

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Timothy R. Mosmann, Holly Cherwinski, M W Bond et al. · The Journal of Immunology · 1986 · 7.5K citations

Adaptive Immune System, T-regulatory Cell, Cellular Immunology +19

T cell receptor antagonist peptides induce positive selection

Kristin A. Hogquist, Stephen C. Jameson, William R. Heath et al. · Cell · 1994 · 2.8K citations

T-regulatory Cell, Immunology, Positive Selection +7

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

Jacques J. Peschon, Philip Morrissey, Kenneth H. Grabstein et al. · The Journal of Experimental Medicine · 1994 · 1.6K citations · Full text

High Affinity Receptor, Lymphocyte Development, T-regulatory Cell +19

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

James P. Lodolce, David L. Boone, Sophia Chai et al. · Immunity · 1998 · 1.3K citations · Full text

Inflammation, Autoimmune Disease, Lymphocyte Homing +11

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

Xiaohong Zhang, Siquan Sun, Inkyu Hwang et al. · Immunity · 1998 · 1.2K citations · Full text

Inflammation, Autoimmune Disease, T-regulatory Cell +8