Acta Physiologica Scandinavica · 1962 · 16 citations · 7 references
MedicinePharmacologyVeterinary PhysiologyExcretionExperimental PharmacologyNeuropharmacologyDrug ExcretionPoultry PharmacologySerotonergic PharmacologySerotonergic SignalingUrinary ExcretionVeterinary NeuropharmacologyBroiler ChickensNeurotransmitter PharmacologyPharmacology Of Serotonergic AgentsRenal Drug ExcretionSerotonergic System EffectsSerotonin PharmacodynamicsTubular Excretion
Abstract Serotonin at a dose of 200 μg given to normal chickens by unilateral leg vein infusion showed an ipsilateral excess of excretion. The excess excretion was below 10 per cent of the dose however. Birds pretreated with a mono amine oxidase inhibitor showed an ipsilateral excess of such a magnitude (26 per cent of the injected dose) that it proves a tubular excretion of serotonin. Reserpine failed to block this process, but a small blocking effect of reserpine cannot be excluded. Urine flow was not significantly altered by the dose of serotonin used in this study.
7