Cancer · 2006 · 39 citations · 20 references
The results suggest that treatment with colchicine prevents and delays the development of HCC in patients with hepatitis virus-related cirrhosis. The protective mechanisms of colchicine over the development of HCC could be related to antiinflammatory properties and inhibition of mitosis. Prospective studies to confirm this observation with a greater number of patients and long-term follow-up may be indicated.
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Hepatocellular Carcinoma in Italian Patients with Cirrhosis
Massimo Colombo, Roberto de Franchis, E. Del Ninno et al. · New England Journal of Medicine · 1991 · 821 citations · Full text
Colchicine in the Treatment of Cirrhosis of the Liver
David Kershenobich, Florencia Vargas, Guadalupe García–Tsao et al. · New England Journal of Medicine · 1988 · 326 citations