Self‐Assembled Bifunctional Catalysis Induced by Metal Coordination Interactions: An Exceptionally Efficient Approach to Enantioselective Hydrophosphonylation

Abstract

Cost effective: Bifunctional catalysts derived from commercially available chiral substituted binols and cinchona alkaloids with Ti(OiPr)4 by spontaneous metal–organic coordination (see picture) promote the asymmetric hydrophosphonylation of aldehydes in up to 99 % yield and greater than 99 % ee. The experimental conditions are capable of tolerating a relatively wide scope of substrates even in the presence of only 2.5 mol % of catalyst. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z801766_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.