Discrimination of β‐Ketoesters by Ruthenium(II)–Binap‐Catalyzed Asymmetric Hydrogenation

Abstract

Please, after you…︁ β-Ketoesters in mixtures underwent Noyori reduction one by one at room temperature under 4 bar of hydrogen pressure in the presence of a catalyst formed from RuII and (S)-binap (see example). The rate of the asymmetric hydrogenation and hence the selectivity for a particular β-ketoester was found to depend on the Lewis basicity of the ester group. Binap=2,2′-bis(diphenylphosphanyl)-1,1′-binaphthyl.