European Journal of Biochemistry · 1978 · 324 citations · 42 references
Life SciencesBiochemistryMolecular BiologyCalcium HomeostasisProtein BiochemistryCalcium Transport ProteinsCalcium-binding ProteinsProtein BindingProtein CharacterizationProtein Sequence AnalysisProtein StructureCalcium-binding MotifCalcium-binding Site StructureCalcium-dependent Protein-protein InteractionsCalmodulin SignalingS100 Binding ProteinsS100 ProteinsS100b Protein
The amino acid sequence of a brain-specific protein, S-100, has been determined by the analysis of four cyanogen bromide peptides and fourteen tryptic peptides derived from the protein. The protein chain consists of 91 amino acid residues and has a molecular weight of 10507. The sequence shows regions of stong clustering of hydrophobic, basic and acidic amino acids, with an apparent calcium-binding site in the acidic cluster.
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Prediction of protein conformation
Peter Y. Chou, Gerald D. Fasman · Biochemistry · 1974 · 3.3K citations