Improvement of myelopathy in Sjogren’s syndrome with chlorambucil and prednisone therapy

Abstract

The authors present a patient with Sjögren's syndrome with a fluctuating and then progressive myelopathic syndrome, and optic nerve involvement. Treatment with chlorambucil and prednisone improved the patient's function from being wheelchair bound to walking unaided. Spinal MRI showed multiple, extensive intraparenchymal areas of abnormal T2-weighted signal intensity, gadolinium enhancement, and cord swelling, which also improved during the period of treatment.

References

Page 1

	Year	Citations
Clinical, CSF, and MRI findings in Devic's neuromyelitis optica. J O’Riordan, Helen L. Gallagher, Alan J. Thompson, Journal of Neurology Neurosurgery & Psychiatry	1996	395
Primary Sjögren's Syndrome with Central Nervous System Disease Mimicking Multiple Sclerosis Elaine L. Alexander Annals of Internal Medicine Definite Multiple SclerosisRheumatologyAutoimmune DiseaseAllergySjögren’s Syndrome	1986	251
THE SPECTRUM OF NEUROLOGICAL INVOLVEMENT IN SJÖGREN'S SYNDROME Andrew P. Andonopoulos, G. Lagos, A. A. Drosos, Lara D. Veeken	1990	132
NEUROLOGIC DISEASE IN SJOGREN’S SYNDROME: MONONUCLEAR INFLAMMATORY VASCULOPATHY AFFECTING CENTRAL/PERIPHERAL NERVOUS SYSTEM AND MUSCLE Elaine L. Alexander Rheumatic Disease Clinics of North America RheumatologyAutoimmune DiseaseVasculitisSjögren’s SyndromeLupus	1993	125
The prevalence of primary sjögren's syndrome in a multiple sclerosis population John H. Noseworthy, B. Bass, Margaret K. Vandervoort, Annals of Neurology	1989	74
SJÖGREN'S SYNDROME: A STUDY OF ITS NEUROLOGICAL COMPLICATIONS Allan Binder, M L Snaith, David Isenberg Lara D. Veeken VasculitisNeurological DisorderImmunologyPathologyRheumatoid Disorder	1988	73
Acute transverse myelopathy successfully treated with plasmapheresis and prednisone in a patient with primary sjöugren's syndrome Yrjöu T. Konttinen, Esko Kinnunen, MARTIN VON BONSDORFF, Arthritis & Rheumatism	1987	59
Primary Sjogren's syndrome in patients with multiple sclerosis Magnhild Sandberg‐Wollheim, T. Axéllm, Bjarne U. Hansen, Neurology	1992	45
Aseptic meningoencephalitis in primary Sjögren's syndrome. Response to plasmapheresis and absence of CNS vasculitis at autopsy. Richard Gerraty, Penelope McKelvie, Edward Byrne PubMed Autoimmune DiseaseVasculitisSjögren’s SyndromeSclerodermaCns Vasculitis	1993	37

Page 1