Inhibition of acute nociceptive responses in rats after i.c.v. injection of Thr⁶‐bradykinin, isolated from the venom of the social wasp, <i>Polybia occidentalis</i>

Abstract

Our data indicate that Thr(6)-BK acts through B(2) bradykinin receptors in the mammalian CNS, evoking antinociceptive behaviour. This activity is remarkably different from that of bradykinin, despite the structural similarities between both peptides. In addition, due to the increased metabolic stability of Thr(6)-BK, relative to that of bradykinin, this peptide could provide a novel tool in the investigation of kinin pathways involved with pain.