Programmed Cell Death Induced by Japanese Encephalitis Virus YL Vaccine Strain or Its Recombinant Envelope Protein in Varied Cultured Cells

Abstract

The JEV-YL vaccine strain had changed cell tropism to liver cells different from other virulent strains which have neural tropism, and in this study we proved that the transient-expressed entire E protein of JEV-YL could induce apoptosis and the mutations of E protein may change the organ tropism of JEV-YL.