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Inhibition of cisplatin‐induced vomiting by selective 5‐hydroxytryptamine M‐receptor antagonism

Wesley D. Miner, Gareth J. Sanger

British Journal of Pharmacology · 1986 · 338 citations · 9 references

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Concepts

Abstract

MDL 72222, the selective 5-hydroxytryptamine (5-HT) M-receptor antagonist, prevented or reduced cisplatin-induced emesis in ferrets. It is suggested that cisplatin-induced, and possibly other cytotoxic drug-induced vomiting may involve a 5-HT M-receptor mechanism.

References

9

Antiemetic Efficacy of High-Dose Metoclopramide: Randomized Trials with Placebo and Prochlorperazine in Patients with Chemotherapy-Induced Nausea and Vomiting

Richard J. Gralla, Loretta M. Itri, Sharon E. Pisko et al. · New England Journal of Medicine · 1981 · 710 citations

, , +17

MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors

John R. Fozard · Naunyn-Schmiedeberg s Archives of Pharmacology · 1984 · 428 citations

, , +16

Neuronal 5-HT receptors in the periphery

John Fozard · Neuropharmacology · 1984 · 329 citations

, , +12

CYTOTOXIC-THERAPY-INDUCED VOMITING IS MEDIATED VIA ENKEPHALIN PATHWAYS

Adrian L. Harris · The Lancet · 1982 · 129 citations

, , +8

Cisplatin-induced emesis in the Ferret: a new animal model.

A P Florczyk, John E. Schurig, William T. Bradner · PubMed · 1982 · 102 citations

, , +14