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Reactions of Sodium Borohydride in Acidic Media; XVI.<sup>1</sup> <i>N</i>-Methylation of Amines with Paraformaldehyde/Trifluoroacetic Acid
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1987
Year
Acidic MediaCombinatorial ChemistryEnantioselective SynthesisEngineeringBiochemistryNatural SciencesOrganic ChemistryTertiary AminesChemistrySodium BorohydrideHalogenationSynthetic ChemistryTrifluoroacetic AcidBiomolecular EngineeringParaformaldehyde/trifluoroacetic Acid
Primary and secondary amines are N-methylated to afford tertiary amines with the combination of paraformaldehyde, sodium borohydride, and trifluoroacetic acid.