The ideal anti-thrombotic drug

Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.

Jeffrey I. Weitz, Monika Hudoba, David Massel et al. · Journal of Clinical Investigation · 1990 · 1.1K citations · Full text

Medicine, Cardiology, Pharmacology +16

Adhesive properties of the beta 3 integrins: comparison of GP IIb-IIIa and the vitronectin receptor individually expressed in human melanoma cells.

Nicolas Kieffer, L A Fitzgerald, D. Wolf et al. · The Journal of Cell Biology · 1991 · 113 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

150-kD von Willebrand factor binding protein extracted from human vascular subendothelium is type VI collagen.

Jacob H. Rand, Niran Patel, Elissa J. Schwartz et al. · Journal of Clinical Investigation · 1991 · 108 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Evidence that the primary binding site of von Willebrand factor that mediates platelet adhesion on subendothelium is not collagen.

Philip G. de Groot, M Ottenhof-Rovers, Jan A. van Mourik et al. · Journal of Clinical Investigation · 1988 · 70 citations · Full text

Medicine, Cell Biology, Cell Adhesion +15