Electro-Ontogenesis of Cerebral Activity

Abstract

As Witteridge⁴¹noted in 1950, there is still a great discrepancy between the enormous literature on the electrical activity of the cerebral cortex and the little agreement on its interpretation. The difficulties in the interpretation of the normal (and abnormal) electroencephalogram (EEG) may spring in part from our attempt to understand the full complexity of adult activity without knowledge of ontogenetically earlier, simpler stages. Though we have systematic studies of the ontogenesis of the EEG in man (Lindsley*; Smith †; Henry,¹⁹1944; Gibbs and Knott,¹⁷1949; Grey Walter,¹⁸1950; Gibbs and Gibbs,¹⁶1953; Kellaway,²⁴1953; Melin,³¹1953), there has been no systematic experimental study on laboratory animals. Instead, we have scattered reports dealing with some aspects of electro-ontogenesis, largely on the guinea pig and rabbit. The study reported here represents an attempt to describe the general trends of postnatal development of the electrical