BJOG An International Journal of Obstetrics & Gynaecology · 1988 · 25 citations · 13 references
MedicineOncologySurgeryChemotherapyGynecologic OncologySurgical OncologyCancer StagingGynecologic Oncology SurgeryOvarian CancerOvarian NeoplasiaOvarian PathologyOvarian SurgeryMalignant Ovarian NeoplasmsMalignant Ovarian TumorsOvarian Cancer ChemotherapyOvarian Cancer TreatmentOvarian Tumor CytologyOvarian Tumor StagingOvarian Tumor SurgeryStaging Laparotomy
Of 267 patients with ovarian cancer FIGO stages III and IV, 157 underwent second-look laparotomy after combination chemotherapy consisting of cis-platinum and cyclophosphamide with and without doxorubicin. At second-look operation 45% had macroscopic tumour, 15% microscopic tumour, and 40% complete pathological response. Survival 3 years after second look was: complete pathological response 74%; microscopic disease 24%; visible tumour less than 1 cm 28%; visible tumour greater than 1 cm 17%; negative cytology 59%; and positive cytology 18%. Of the patients with macroscopic tumour, 29% had all visible tumour removed at second look. Three-year survival for these patients was about 45%.
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