Preparation of bonelike apatite composite for tissue engineering scaffold

Abstract

A novel sponge composed of a poly (lactic acid) composite skeleton covered with bonelike apatite (b-HA) was produced via a particle-leaching technique combined with a biomimetic processing. The sponge has a large porosity of ∼75% with large-sized pores and shows mechanical ductility. After incubation of human osteoblasts for 7 days, numerous cells attached to the surface of the skeleton, which was covered with b-HA. One result of the osteoclastic cell culture showed that the b-HA on the composite has excellent bioresorbability. The sponge is expected to be one of the promising candidates for bone tissue engineering scaffolds.