Concepedia

Studies on the Total Synthesis of RP 66453:  Synthesis of Fully Functionalized 15-Membered Biaryl-Containing Macrocycle

Sabine Boisnard, Anny‐Claude Carbonnelle, Jieping Zhu

Organic Letters · 2001 · 44 citations · 8 references

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Concepts

Abstract

[structure: see text] Palladium-catalyzed Suzuki cross-coupling, Corey's enantioselective alkylation of glycine template, and macrolactamization are key steps in an efficient synthesis of the 15-membered macrocycle 2.

References

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Total Synthesis of an Antitumor Agent RA-VII via an Efficient Preparation of Cycloisodityrosine

Antony Bigot, Marie Elise Tran Huu Dau, Jieping Zhu · The Journal of Organic Chemistry · 1999 · 50 citations · Full text

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