Synthetic Communications · 2008 · 31 citations · 11 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistryOrganic SynthesisSolvent-free SynthesisAldehydesReaction Yield Improvement
Abstract The influence of the substrate structure and concentration on the yield of the Passerini reaction was studied. A new, solvent‐free methodology for a convenient preparation of α‐acyloxyamides 4 was established and compared to the classical methodology. A higher reaction yield was obtained in shorter time, especially in the case of aromatic aldehydes.
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