NEW CROSS ALDOL REACTIONS. THE REACTIONS OF SILYL ENOL ETHERS WITH KETO ESTERS PROMOTED BY TITANIUM TETRACHLORIDE

Abstract

Abstract It was found that, in the presence of TiCl4, keto esters such as ethyl pyruvate, ethyl 2,2-dimethyl acetoacetate, ethyl levulinate and ethyl 5-oxohexanoate react with various trimethylsilyl enol ethers derived from ketones at room temperature to afford cross aldols, i.e., hydroxy keto esters, in good yields.