Synthesis of New Chiral Ligands Based on Thiophene Derivatives for Use in Catalytic Asymmetric Oxidation of Sulfides

Abstract

For example, the biological activitiesof sulfoxide containing drugs such as omeprazole arestrongly related to the chirality of the sulfoxide group; forthis reason, esomeprazole, the enantiomerically pure form ofomeprazole, was later developed. There are several chiralsulfoxide based drugs that have been introduced by thepharmaceutical industry including armodafinil, aprikalim,oxisurane, and ustiloxin. Chiral sulfoxides have also beenutilized as chiral auxiliaries in asymmetric syntheses ofchiral intermediates.