Inhibition of insulin‐like growth factor binding protein 5 proteolysis in articular cartilage and joint fluid results in enhanced concentrations of insulin‐like growth factor 1 and is associated with improved osteoarthritis

Abstract

The findings suggest that direct inhibition of the serine protease C1s results in increased concentrations of intact IGFBP-5 and that proteolysis of IGFBP-3 is also inhibited, probably by the inhibition of some other protease. This increase in concentrations of intact IGFBP-3 and IGFBP-5 leads to an increase in IGF-1 which is associated with an improvement in joint architecture during the development of OA.