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SEX HORMONES – EFFECTS ON PROLACTIN CELLS IN THE RAT, DOG, MONKEY AND MAN
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1974
Year
FertilitySex HormonesGynecologyFemale Reproductive FunctionReproductive BiologyAnterior PituitaryReproductive EndocrinologyPituitary GlandPublic HealthInfertilityEndocrine MechanismMonkey And ManEndocrinologyProlactin SecretionUterine ReceptivityPhysiologyMedicineEndocrine ResearchReproductive Hormone
ABSTRACT Histomorphological and immunocytochemical methods were used to study the effect of either physiological and pathological endogenous production or long-term exogenous application of high doses of sex (steroid) hormones on the prolactin cells in the anterior pituitary of experimental animals and man. Using these methods it was shown that enhanced endogenous secretion of sex hormones, mainly of oestrogens, seems to produce nearly the same morphological changes in the anterior pituitary of the rat, dog and man. It was also possible to show that long term exogenous application of high doses of oestrogens or oestrogens and progestagens can stimulate prolactin cells in some experimental animals. The demonstration of similar mechanisms in man calls for more extensive investigations on the possible role of the sex hormones on prolactin secretion.