Gigantetrocin and Gigantriocin: Two Novel Bioactive Annonaceous Acetogenins from Goniothalamus giganteus

Abstract

The structural elucidations of gigantetrocin and gigantriocin, two novel bioactive monotetrahydrofuran acetogenins with vicinyl hydroxyls are presented. These compounds are significantly and selectively cytotoxic to human tumor cells in culture and toxic to brine shrimp, and they inhibit the formation of crown gall tumors on potato discs, showing good potential for in vivo antitumor activities