Saikosaponin D disrupts platelet-derived growth factor-β receptor/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: A potential mechanism of hepatotoxicity

JNK- and p38 Kinase-mediated Phosphorylation of Bax Leads to Its Activation and Mitochondrial Translocation and to Apoptosis of Human Hepatoma HepG2 Cells

Bong‐Jo Kim, Seung‐Wook Ryu, Byoung‐Joon Song · Journal of Biological Chemistry · 2006 · 466 citations · Full text

Life Sciences, Biochemistry, Cell Biology +16

Bioelectrical impedance assay to monitor changes in cell shape during apoptosis

S. Arndt, Jochen Seebach, Katherina Psathaki et al. · Biosensors and Bioelectronics · 2003 · 313 citations

Natural Sciences, Biophysics, Cell Biology +14

Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-κB signaling pathway

Chunni Lu, Zi‐Guo Yuan, Xiaoli Zhang et al. · International Immunopharmacology · 2012 · 194 citations · Full text

Life Sciences, Cell Biology, Immunology +10

Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.

Yun Dai, Chendi Yu, Vibha Singh et al. · PubMed · 2001 · 161 citations

Medicine, Oncology, Pharmacology +17

MAPK signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells

Yuan Li, Jing Wang, Haifang Xiao et al. · Food and Chemical Toxicology · 2012 · 109 citations

Life Sciences, Cancer Biology, Oncology +14