Catalytic Enantioselective Passerini Three‐Component Reaction

Abstract

Make it enantioselective: The [(salen)AlIIICl] complex 1 catalyzes the title reaction of an aldehyde, a carboxylic acid, and an isocyanide to afford α-acyloxyamides 2 with good to excellent enantioselectivity. A variety of nonchelating substrates can be used to generate the versatile chiral products. R1=alkyl; R2=alkyl, alkenyl, aryl; R3=alkyl, aryl. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z704315_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.