Kinetics of triglyceride turnover of very low density lipoproteins of human plasma.

Abstract

Ahrens and co-workers (1) have collated and extended prior observations (2-7) that high car- bohydrate, low fat diets may cause hypertriglyceridemia in certain subjects. They termed this phenomenon "carbohydrate-induced lipemia" (1). Despite uncertainties concerning the degree or duration of plasma triglyceride rise needed to merit this appellation, this general response to a high carbohydrate diet is frequently observed in patients with evidence for accelerated atherogenesis (1, 8-10). Furthermore, elevated plasma triglycerides are common in patients with "pre- mature" arteriosclerotic heart disease on ad libitum diets Consequently, it becomes im- portant to define the factors controlling plasma triglyceride concentration in man.