Clinical significance and association of RUNX3 hypermethylation frequency with colorectal cancer: a meta-analysis

Wei-Ping Mu, Jian Wang, Qiong Niu, Ning Shi, Haifeng Lian

OncoTargets and Therapy · 2014 · 20 citations · 33 references

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Abstract

The results of this meta-analysis suggest that RUNX3 hypermethylation is associated with an increased risk of CRC, increased risk of progression of CRC, and a poorer CRC survival rate. RUNX3 hypermethylation, which induces the inactivation of RUNX3 gene, plays an important role in colorectal carcinogenesis, high levels of MSI, as well as CRC progression and development.

References

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