Journal of the American Medical Association · 1944 · 21 citations · 0 references
PharmacyPharmacologyPharmacotherapyCritical Care PharmacologyDrug Utilization ReviewPharmaceutical ToxicologyAdverse Drug Reaction ManagementAdverse Drug Reaction MonitoringAdverse Drug ReactionsDrug Safety MonitoringDrug Toxicity
In the past four years 1,936 patients in the medical wards at the Cincinnati General Hospital have been treated with sulfathiazole, sulfadiazine, sulfapyrazine, sulfaguanidine and succinylsulfathiazole. Sulfapyridine is now considered obsolete and is no longer used in this service, sulfanilamide is rarely employed and only a preliminary report can be given on sulfamerazine, since its use has been recent. This particular study was undertaken to determine the relative incidence of untoward reactions to the various drugs and the relation of the mild and readily recognizable symptoms to severely toxic or lethal reactions. Difficulties were encountered in this evaluation because many patients admitted to this service are critically ill as the result of acute infection or are in a moribund state of chronic disease, and thus the division of symptoms due to drug and those due to disease is difficult. Also the drug is usually discontinued at the first sign suggestive