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Total Synthesis of Brevetoxin A: Part 4: Final Stages and Completion
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1999
Year
Diversity Oriented SynthesisBiosynthesisBioorganic ChemistryEngineeringBiochemistryNatural Product SynthesisTen-year CampaignNatural SciencesDiversity-oriented SynthesisCross-coupling ReactionTotal SynthesisOrganic ChemistryPart 4ChemistryPharmacologySynthetic ChemistryBiomolecular EngineeringBrevetoxin A
A ten-year campaign was successfully completed by the first total synthesis of brevetoxin A (1). A Horner–Wittig type coupling of suitably functionalized BCDE and GHIJ ring systems proved to be the last key step in the total synthesis of this architecturally beautiful molecule.