Negative regulation of the<i>pts</i>operon by Mlc: mechanism underlying glucose induction in<i>Escherichia coli</i>

Abstract

We conclude that Mlc is a repressor for the pts transcription acting as a major regulatory protein involved in the glucose induction of pts operon. We propose that glucose induces the pts transcription by modulating the Mlc activity. The mechanism by which glucose modulates the Mlc action remains to be studied.