Iron Stores Modulate Hepatic Hepcidin Expression by an <i>HFE</i>-Independent Pathway

Abstract

The central pathogenetic step in HFE-related hemochromatosis is an impaired basal expression of HAMP rather than a lack of HAMP upregulation in response to iron stores. An HFE-independent pathway that seems to involve TFR2 and HJV can regulate HAMP expression under conditions of iron overload.