SERUM SICKNESS AND ANAPHYLAXIS

Abstract

<h3>TABLE OF CONTENTS</h3> Fatal Cases Factors Influencing the Incidence of Serum Sickness and Anaphylaxis Kind of Serum Age and Sex Race Amount of Serum Injected Route of Administration Preparation of Serum Age of Serum Horse Producing Serum Repeated Injections Serum Sickness in Animals Serum Rash Types Recurrence Onset of Serum Sickness Duration of Serum Sickness Symptoms of Serum Sickness Fever Edema Adenopathy Arthritis Gastrointestinal Tract Complications Respiratory System Complications Cardiovascular-Renal Complications Endocrine Complications Mental Complications Central Nervous System Complications Peripheral Nervous System Complications Miscellaneous Complications Secondary Injections Passive Sensitization to Horse Serum Transferred Through the Use of Human Convalescent Serum Arthus Phenomena Reported in the Literature Diagnostic Intradermal Test Classification of Persons Giving Positive Reactions to the Intradermal Test Route Factor Cases of Spontaneous Sensitivity Positive Reactions to Intradermal and Conjunctival Tests Reported in the Literature Diagnosis Mechanism Prevention Treatment Thermal Reaction Comment Summary and Conclusions As late as 1932 Park¹claimed that the mortality from serum anaphylaxis was only 1 in 50,000, a ratio which is still quoted by almost all American writers, e. g. Coca,²Taylor,³Mackenzie and Hanger,⁴Cooke⁵and Zinsser.⁶In Europe Pfaundler's⁷