Publication | Closed Access
Tandem Addition/Cyclization of Alkynylzinc Reagents to Enantiopure 2‐<i>tert</i>‐Butyl‐3,5‐dimethyl‐2,3‐dihydroimidazol‐4‐one <i>N</i>‐Oxide: Potential Precursors of Quaternary α‐Amino Acids
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Citations
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References
2005
Year
Tandem Addition/cyclizationEngineeringNatural SciencesTandem Addition/cyclization ReactionDiversity-oriented SynthesisAlkynylzinc ReagentsOrganic ChemistryStereoselective SynthesisChemistryHeterocycle ChemistryPotential PrecursorsAsymmetric CatalysisQuaternary α‐Amino AcidsEnantioselective SynthesisBiomolecular Engineering
Abstract A new enantiopure cyclic nitrone, a potential electrophilic alanine synthon, has been prepared. Its reaction with alkynylzinc reagents led to a tandem addition/cyclization reaction with complete regio‐ and stereoselectivity. The adducts are potential precursors of quaternary α‐amino acids. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
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