Publication | Closed Access
<sup>19</sup>F, <sup>13</sup>C NMR analysis of an oxygen carrier, perfluorotributylamine, and perfluoropentanoic acid
12
Citations
43
References
2003
Year
EngineeringC NmrMagnetic ResonanceOrganic ChemistryPerfluoropentanoic AcidChemistrySpectra-structure CorrelationAnalytical ChemistryClinical ChemistryOxygen ConcentrationsMolecular ImagingNuclear MedicineRelaxometryMolecular SciencesBiochemistryF Nmr AssignmentsFluorous SynthesisBiomedical AnalysisSolution Nmr SpectroscopyPharmacologyMagnetic Resonance SpectroscopyResonanceProtein NmrOxygen CarrierMedicineNuclear Magnetic Resonance SpectroscopyDrug Analysis
Abstract NMR relaxation measurement of perfluorocarbons (PFCs), such as perfluorotributylamine (FTBA), is a convenient method for the determination of oxygen concentrations in tissues and tumors. Previous relaxation studies of FTBA used different 19 F NMR assignments causing some confusion. Fluorine‐detected 19 F, 13 C HMQC and HMBC and selectively 19 F‐decoupled 13 C NMR provided unequivocal 19 F and 13 C assignments for FTBA and perfluoropentanoic acid (FPA). Based on those assignments, 13 C spin–lattice relaxation time constants ( T 1 ) and effective correlation times for FTBA and FPA are reported and discussed. Copyright © 2003 John Wiley & Sons, Ltd.
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