Publication | Open Access
On the extent of racemization of allylic esters during palladium—mediated alkylation with homochiral 3-methyl-δ-butyrolactone derivatives
22
Citations
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References
1986
Year
Cross-coupling ReactionEngineeringAllylic EstersBiochemistryAllylic Phosphate 4ENatural SciencesSodium LactoneOrganic ChemistryCatalysisChemistryHomochiral 3-Methyl-δ-butyrolactoneAsymmetric CatalysisPalladium—mediated AlkylationEnantioselective SynthesisBiomolecular EngineeringAcetate 4D
The allylic phosphate 4e has been shown to racemize 4̃–6% upon alkylation with the sodium lactone enolates of 1c and ent-1c in the presence of Pd(Ph3P)4. The acetate 4d racemizes 11%.
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