Peptide Specificity, HLA Class II Restriction, and T–Cell Subsets of the T–Cell Clones Specific to Either Cry j 1 or Cry j 2, the Major Allergens of Japanese Cedar (Cryptomeria japonica) Pollen

Abstract

No clear correlation existed between peptide specificity, HLA class II restriction and induction of Th-cell subsets, suggesting that the requirement of different dose of Cry j 1 or Cry j 2 to induce proliferation in PBMC may lead to distinguishable difference in induction of Th subsets between TCCs specific to Cry j 1 and Cry j 2.