A Comparison of Methods Used in Determining the Time of Ovulation1

Abstract

ALL INDIRECT METHODS used in attempting to determine the time of ovulation in women are open to the criticism that it is not ovulation, but something else, which is being studied. On the other hand, such direct methods as the inspection of ovaries at laparotomy, and the recovery of eggs from the tubes, also have their shortcomings. In addition to the limitations imposed by the necessary surgical procedures, the direct methods usually permit only one observation on a given subject, they give little information of underlying physiologic mechanisms and they are not entirely objective, as the interpretation of the stage of development observed rests on the judgment of the investigator. Indirect methods, therefore, have their place, in spite of fundamental weaknesses and what is required is the establishment of their validity as tests for ovulation. It is now generally accepted that ovulation usually occurs during the mid-interval of the menstrual cycle, and that it is under hormonal control.