Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour

Mast cell tryptase is a mitogen for cultured fibroblasts.

Stephen J. Ruoss, Tobias Hartmann, George H. Caughey · Journal of Clinical Investigation · 1991 · 392 citations · Full text

Life Sciences, Biochemistry, Cell Biology +15

Human mast cells activate fibroblasts: tryptase is a fibrogenic factor stimulating collagen messenger ribonucleic acid synthesis and fibroblast chemotaxis

Barry L. Gruber, Richard R. Kew, Ante Jelaska et al. · The Journal of Immunology · 1997 · 307 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2

Ian Arthur Akers, Maddy Parsons, Michael Hill et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2000 · 306 citations

Life Sciences, Cell Biology, Immunology +12

Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARγ: Possible relevance to human fibrotic disorders

Mónica Beatriz Frungieri, Stephan Weidinger, Viktor Meineke et al. · Proceedings of the National Academy of Sciences · 2002 · 249 citations

Life Sciences, Immunology, Pharmacology +16

Human mast cells stimulate fibroblast proliferation, collagen synthesis and lattice contraction: a direct role for mast cells in skin fibrosis

Ekaterina Garbuzenko, Arnon Nagler, Dalia Pickholtz et al. · Clinical & Experimental Allergy · 2002 · 224 citations

Life Sciences, Dermatology, Immunology +17