QUATERNARY AMMONIUM SALT-ASSISTED SYNTHESIS OF EXTENDED π-SYSTEMS FROM METHYLDIAZINES AND AROMATIC ALDEHYDES¹

Abstract

4-Methyl- and 4,6-dimethylpyrimidines, methyl- and 2,5-dimethylpyrazines, as well as 3-methylpyridazine readily react with aromatic aldehydes in a hot solution of sodium hydroxide in the presence of a catalytic amount of a quaternary ammonium salt and in the absence of any organic solvent to yield the corresponding condensation products.