Detection of Leishmania donovani soluble antigen and antibody in the urine of visceral leishmaniasis patients

Abstract

Urine samples from 21 patients with visceral leishmaniasis were examined for the presence of Leishmania donovani soluble antigen and antibody by double counter-current immunoelectrophoresis. 19 samples revealed both antigen and antibody (IgM in 5 and IgG in all samples). 2 urine samples collected 10 and 13 days after Glucantime treatment revealed only antibody (IgG), not soluble antigen.