Chemistry - A European Journal · 1999 · 334 citations · 0 references
MedicineMedicinal ChemistryNuclear MedicineOncologic Nuclear MedicineRadionuclide TherapyTherapeutic Nuclear MedicineRadiation TherapyRadiopharmaceutical DesignRadiopharmaceutical TherapyRadiopharmaceuticalsTargeted Radionuclide TherapyTargeted RadiopharmaceuticalsBeta-emitting RadionuclidesBiodistribution EnhancementBiodistribution StudiesInternal RadiotherapyPeptide RadiopharmaceuticalsPeptide-based RadiopharmaceuticalsPeptide-based RadiotracersSomatostatin Analogues
A highly stable octacoordinated Y-DOTA-D-Phe-amide (see picture) allows the first use of the powerful β-emitter 90Y, coupled to a bioactive peptide, in internal radiotherapy of cancer. The same peptide labelled with the γ-emitter, 67Ga, shows improved biodistribution as a consequence of the hexacoordination of the GaIII complex with a pendant, ionised, acetic acid group.