Concepedia

Chiral Phosphoric Acid Catalyzed Enantioselective Desymmetrization of <i>meso</i>-Epoxides by Thiols

Zhaobin Wang, Wai Kit Law, Jianwei Sun

Organic Letters · 2013 · 71 citations · 47 references

DOI

Concepts

Abstract

The first chiral Brønsted acid catalyzed asymmetric nucleophilic ring-opening reaction of meso-epoxides is described. In the presence of TRIP, a range of meso-epoxides could undergo smooth ring-opening reactions by aryl thiols with good efficiency and enantioselectivity.

References

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Highly Enantioselective Ring Opening of Epoxides Catalyzed by (salen)Cr(III) Complexes

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