Concepedia

Method development and validation of the simultaneous determination of a novel topoisomerase 1 inhibitor, the prodrug, and the active metabolite in human plasma using column-switching LC–MS/MS, and its application in a clinical trial

Tomonori Kamei, Takahide Uchimura, Kazuhiro Nishimiya, Takehiko Kawanishi

Journal of Chromatography B · 2011 · 11 citations · 21 references

DOI

Concepts

References

21

A kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some Analogues

Julianne Fassberg, Valentino J. Stella · Journal of Pharmaceutical Sciences · 1992 · 464 citations

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Breast Cancer Resistance Protein Directly Confers SN-38 Resistance of Lung Cancer Cells

Shigeru Kawabata, Mikio Oka, Ken Shiozawa et al. · Biochemical and Biophysical Research Communications · 2001 · 239 citations

, , +12

In Vitro-In Vivo Correlation for Intrinsic Clearance for Drugs Metabolized by Human Aldehyde Oxidase

Michael Zientek, Ying Jiang, Kuresh Youdim et al. · Drug Metabolism and Disposition · 2010 · 126 citations

, , +15

Reversed-phase high-performance liquid chromatographic method for the simultaneous quantitation of the carboxylate and lactone forms of the camptothecin derivative irinotecan, CPT-11, and its metabolite SN-38 in plasma

Laurent P. Rivory, Jacques Robert · Journal of Chromatography B Biomedical Sciences and Applications · 1994 · 110 citations

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Determinants of CPT-11 and SN-38 activities in human lung cancer cells

J van Ark-Otte, MA Kedde, WJF van der Vijgh et al. · British Journal of Cancer · 1998 · 93 citations · Full text

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