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Synthesis, Characterization and Antitumour Activities of Di‐n‐Butyl‐ and Dimethyltin D‐(+)‐Camphorates
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1998
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Medicinal ChemistryDerivative (Chemistry)BiochemistryTumoural Cell LinesDisplays Antitumoural ActivityNatural SciencesMedicineDimethyltin D‐Anti-cancer AgentAntitumour ActivitiesPharmacologyRadiation OncologyPharmaceutical ChemistrySynthetic ChemistryDrug DiscoveryNatural Product Synthesis
The synthesis and characterization di‐n‐butyl‐ and dimethyltin D‐(+)‐camphorates, respectively compounds 1 and 2, are reported. Compound 1 displays antitumoural activity in vitro , and is more active than cisplatin, 5‐fluorouracil and etoposide against seven tumoural cell lines of human origin, but less active than methotrexate and doxorubucin.