Experimental demonstration of the unstirred water layer effect on drug transport in Caco-2 cells

Substantial excretion of digoxin via the intestinal mucosa and prevention of long‐term digoxin accumulation in the brain by the mdrla P‐glycoprotein

Ulrich Mayer, Els Wagenaar, Jos H. Beijnen et al. · British Journal of Pharmacology · 1996 · 280 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +16

Transcellular Transport of Benzole Acid Across Caco-2 Cells by a pH-Dependent and Carrier-Mediated Transport Mechanism

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Engineering, Biophysics, Physiology +10

Influence of Passive Permeability on Apparent P-glycoprotein Kinetics

Kimberley A. Lentz, Joseph W. Polli, James E. Polli et al. · Pharmaceutical Research · 2000 · 126 citations

Pharmacy, Pharmacokinetics, Pharmacology +9

Carrier-Mediated Mechanism for the Biliary Excretion of the Quinolone Antibiotic Grepafloxacin and Its Glucuronide in Rats

Hiroyuki Sasabe, Akira Tsuji, Yuichi Sugiyama · Journal of Pharmacology and Experimental Therapeutics · 1998 · 77 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Involvement of Multidrug Resistance-Associated Protein 2 in Intestinal Secretion of Grepafloxacin in Rats

Kazumasa Naruhashi, Ikumi Tamai, Natsuko Inoue et al. · Antimicrobial Agents and Chemotherapy · 2002 · 76 citations · Full text

Medicine, Pharmacology, Biochemical Pharmacology +16