Comparison of the Antitumor Effect of Interferon and Interferon Inducers

Abstract

A comparison of the antitumor effect of IF and IF inducers (NDV, statolon, poly I·poly C, and poly A·poly U) was made in vitro and in vivo.In vitro three IF inducers (NDV, statolon, poly I·poly C) and IF were highly effective in inhibition of focus formation by MSV. In mice, NDV, statolon and poly I·poly C were equally effective as antitumor agents. IF and poly A·poly U at the dose level used were not effective. In hamsters, the antitumor effects of the inducers were much less pronounced than they were in mice.