Photochemistry and Photobiology · 1971 · 90 citations · 29 references
Life SciencesBiochemistryMolecular BiologyDna RepairNucleic Acid BiochemistryRadiobiologyDna DamageDna Strand BreaksSingle-strand Break RepairDna Repair MechanismsDna Strand Break RepairLight-dependent Dna RepairRepair Of Ionizing Radiation-induced BreaksRepair Of Uv-induced Dna DamageUltraviolet-induced Dna DamageUv-induced Dna Lesions
Abstract— –The repair of u.v. damaged DNA in HeLa cells can be detected using the alkaline sucrose gradient technique. As a result of pyrimidine dimer excision single strand breaks are produced in DNA of irradiated cells. Rejoining of these breaks occurs during an 8 hr post‐irradiation incubation period and is prevented by hydroxyurea and acriflavine. The inhibition of repair by hydroxyurea can be reversed by a mixture of all 4 deoxyribonucleosides at a concentration that does not reverse the inhibition of total DNA synthesis.
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Defective Repair Replication of DNA in Xeroderma Pigmentosum
James E. Cleaver · Nature · 1968 · 1.7K citations
Isolation of an E. coli Strain with a Mutation affecting DNA Polymerase
PAULA DE LUCIA, John Cairns · Nature · 1969 · 753 citations