Journal of Pharmacy and Pharmacology · 1989 · 77 citations · 6 references
PharmacyMaterials EngineeringMaterials ScienceDosage Form DesignMechanical Behavior Of MaterialsPreformulation StudiesPowder ProcessingPowder TechnologyTablet DesignTablet TechnologyPowder Bed MaterialsPowder CompressibilitySpeedTablet Compaction BehaviorTablet Compression EffectsTablet Pressing
The reduction in porosity of a powder bed on compression was found to be a function of the velocity of the punch of the press. Substances which consolidated principally by fragmentation showed relatively little velocity dependence. However, the more important deformation was in a powder's consolidation mechanism, the greater the dependence on punch velocity and hence tablet press speed.
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