Angiotensin II Regulation of Renal Dopamine Uptake and Na<sup>+</sup>,K<sup>+</sup>-ATPase Activity

Abstract

Stimulation of renal AT(1) receptors by ANG II signals through the PLC pathway to inhibit extraneuronal DA uptake. DA and ANG II act through a common pathway involving reversible renal tubular Na(+),K(+)-ATPase deactivation and activation, respectively. In addition, ANG II by itself is able to stimulate renal Na(+),K(+)-ATPase activity.